Absolutely! And often more so than many other payment methods!
PayFast is PCI DSS Level 1 Service Provider (the highest level).
PayFast is developed with the same demands on security and performance as web sites used for banking services and share trading. Your account login, personal details, and all money transactions are secured using Secure Socket Layer (SSL) technology with high security 256 bit encryption.
Your sensitive financial information (like credit/debit card details) is never sent to the people you pay! So you can send money without sending your financial information! So you don't need to worry about paying people you don't know.
We make use of 3D Secure to further enhance the security of credit card transactions on PayFast.